Many plants are considered wild or weed with no economic value, Argemone mexicana L. is one such widely growing neglected weed in almost all the regions of India. Argemone mexicana, aka; Satyanashi commonly known as prickly poppy, is a spiny plant native to subtropical regions and widely recognized for its medicinal properties. It has been traditionally used in Ayurvedic, Unani, Siddha, and Homeopathic medicine for several years. Each part of the plant contains bioactive compounds that contribute to the treatment of various ailments, including HIV, malaria, ringworm infections, fungal diseases, and cancer. These therapeutic effects have been examined through both in vivo and in vitro studies, with findings supporting its medicinal potential. The leaves, stem, latex, roots, and seeds of Argemone mexicana L. exhibit diverse pharmacological properties. Several phytochemical compounds extracted from its seeds have shown effectiveness in treating chronic diarrhea, dysentery, peptic ulcers, and respiratory infections. This study has outlined the medicinal uses, phytochemical composition, and potential adverse effects associated with the plant.
Introduction
Medicinal plants have been used since ancient times due to their bioactive phytochemicals, which provide therapeutic effects with minimal side effects. Argemone mexicana, or Mexican poppy, is a spiny annual herb from the Papaveraceae family, widely distributed in tropical and subtropical regions. It possesses numerous medicinal properties including analgesic, antispasmodic, anti-inflammatory, wound-healing, and antimicrobial effects. Despite misconceptions about its toxicity, the plant itself is generally safe; toxicity arises mainly from adulterated oils.
Morphologically, it features thorny leaves, yellow flowers, and seed capsules, producing a distinctive yellow latex and light-yellow oil from seeds. Traditionally used in Ayurveda and other folk medicines, Argemone mexicana treats ailments like jaundice, skin diseases, inflammation, infections, and malaria, with additional roles as an expectorant and digestive aid.
Phytochemical screening reveals the presence of alkaloids, flavonoids, tannins, terpenoids, steroids, glycosides, and saponins—compounds responsible for its medicinal effects. The plant shows strong antioxidant and antimicrobial activities, inhibiting bacteria, fungi, and viruses.
Though it acts as a problematic weed affecting crops and livestock due to toxic aflatoxins and allelopathic effects, Argemone mexicana remains a valuable medicinal resource. Continued research is essential to isolate its active compounds and develop plant-based pharmaceuticals, highlighting its potential in sustainable natural medicine.
Conclusion
Phytochemical analysis of Argemone mexicana has identified the presence of secondary metabolites such as alkaloids, flavonoids, tannins, terpenoids, steroids, and glycosides. These bioactive compounds play a crucial role in medicinal applications. Further extensive research on the plant\'s pharmacological properties is necessary to isolate and evaluate its active phytochemicals, potentially leading to the development of significant plant-based pharmaceutical products. A weed can serve as a valuable medicinal resource if its properties and effects are well understood. Continuous research and development are essential to fully explore its qualities and therapeutic applications. Based on numerous studies, Argemone mexicana L. despite often being overlooked, has demonstrated significant potential in addressing various health concerns. This resilient plant, native to arid regions, offers a wide array of benefits and serves as an important source of diverse chemical compounds with various medicinal properties.
References
[1] Abbasi, I. J. B. A, T. Mahmood, K. S. B. Ali, S. A. Shah and A. T. Khalil (2017) Plant-derived anticancer agents: A green anticancer approach. Asian Pacific J. Trop. Biomed. 7:1129-1150.
[2] Agra, M. F., G. S. Baracho, K. Nurit, I. J. L. D. Basilio and V. P. M Coelho (2007) Medicinal and poisonous diversity of the flora of “CaririParaibano”, Brazil. J. Ethnopharmacol. 111: 383-395.
[3] Alagesaboopathi, C., N. Kalaiselvi (2012) Antimicrobial activities of the root, stem and leaf extracts of Argemone mexicana L. Int. J. Biosci. 2: 61-68. Amartha, S. and S Chaudhari (2011) Neuropharmacological study of Argemone mexicana Linn. J. App. Pharm. Sci.1: 121-126.
[4] Avello, S. P. C (2009) Investigation of antiplasmodial compounds from various plant extracts Thèse de doctorat. Univ. Genève. no. Sc; 4129.
[5] Badami, R. C and F. D. Gunstone (1962) Vegetable oils. X. Examination of component acids of Argemone mexicana seed oil by reversed-phase chromatography. J. Sci. Food. Agric. 13: 255-257.
[6] Bhardwaj, D. K., M. S. Bisht, R. K. Jain and A. Munyal (1982) Phenolics from the seeds of Argemone mexicana. Phytochem. 21: 2154-2156
[7] Bhardwaj, M, Surekha and J. S Duhan (2011) Free radical scavenging and antimutagenic potential of acetone, chloroform and methanol extracts of leaf of Argemone mexicana. Int. J. Pharm. Bio. sci. 2: 455-464.
[8] Bhardwaj, M., J. S. Duhan, A. Kumar and Surekha (2012) Antimicrobial potential of Argemone mexicana: An in vitro study. Asian J. Microbiol. Biotechnol. Environ. Sci. 14: 353-357.
[9] Bhattacharjee I. et al., Isolation and identification of antibacterial components in seed extracts of Argemone mexicana L. (Papaveraceae). Asian Pacific Journal of Tropical Medicine 2010; 3:547-51.
[10] Brahmachari G. et al., A new long-chain alkanediol from the flowers of Argemone Mexicana L. J. Chem. Res. 2010; 11:656-67.
[11] Brahmachari G. et al., Argemone Mexicana L.: chemical and pharmacological aspects. Brazilian Journal of Pharmacognosy 2013; 23: 559-75.
[12] Brahmachari, G., R. Roy, L. C. Mandal, P. P. Ghosh and D. Gorai (2010) A new long-chain alkanediol from the flowers of Argemone mexicana. Braz. J. Pharmacog. 11: 656-657.
[13] Chang Y.C. et al., Cytotoxic Benzophenanthridine and Benzylisoquinoline Alkaloids from Argemone Mexicana L. Z. Naturforsch. 2003; 58: 521-526.
[14] Chang, Y. C., F. R Chang, A. T Khalil, P. W Hsieh and Y. C Wu (2003) Cytotoxic benzophenanthridine and benzylisoquinoline alkaloids from Argemonemexicana. Z. Naturforsch. 58: 521-526
[15] Dalvi, R. R (1985) Sanguinarine: its potential, as a liver toxic alkaloid present in the seeds of Argemone mexicana. Experientia. 41: 77-78.
[16] Dash & Murthy, Evaluation of Argemone mexicana Linn. leaves for wound healing activity, J Nat Prod Plant Resour,2011, 1: 46-56.
[17] Gupta R.S. et al., Antifertility studies of isoquioline alkaloids with special emphasis on structure activity relationship. Fitoterapia. 1990, 61(1): 67-71.
[18] Haisova K.Y.&Savik J. On the minor alkaloids from Argemone Mexicana L. Collection of Czechoslovak Chemical Communications. 1975; 40:1576.
[19] Israilov I.A.&Yunusov M.S. Alkaloids of four species of Argemone Mexicana L.. Chemistry of Natural compounds. 1986; 22:189-192.
[20] Kenneth W. & Bentley: ? - Phenylethylamines and the isoquinoline alkaloids. Natural Product Reports. 2001; 18: 148–170.
[21] Khan A.M. &Bhadauria S., Analysis of medicinally important phytocompounds from Argemone Mexicana L., Journal of King Saud University-Science 2019; 31:1020-26.
[22] Rastogi R. P. &Mehotra B. N. Compendium of Indian Medicinal Plants, Vol. II, CDRI, Lucknow, 1979, 446.
[23] Santos A.C. &Adkilen P. The alkaloids of Argemone Mexicana L. Journal of the American Chemical Society. 1932; 54: 2923.
[24] Singh S. et al., Alkaloids and flavonoids of Argemone Mexicana L., Nat Prod Res 2012; 26:16-21.
[25] Stary F. & Hans. The National guides to medical herbs and plants. Tiger Books, Int Plc. UK. 1998.